Key result
Subtotal resection of LV myxoma preserves mitral function with zero recurrence at ~23 months.
Why the study?
Ventricular cardiac myxomas are rare, and their pseudoinvasive growth can mimic malignancy, posing significant diagnostic challenges.
Case Report (n=1)
No
Multimodal imaging (especially CMR and PET/CT) effectively differentiates benign pseudoinvasive ventricular myxomas from malignancies, enabling conservative subtotal resection that preserves mitral valve integrity without recurrence.
Supports imaging-guided conservative resection to spare mitral valve in rare LV myxomas; leaves open validation in larger cohorts.
BACKGROUND: Cardiac myxomas most commonly originate in the left atrium, whereas occurrences in the ventricles are rare, accounting for only 3% to 4% of cases. Their pseudoinvasive growth, which can mimic malignancy, poses significant diagnostic challenges. CASE SUMMARY: = 7.8) on positron emission tomography/computed tomography. Histopathological examination confirmed the mass as a benign myxoma with pseudoinvasive entrapment of the papillary muscle. Subtotal resection was performed, successfully maintaining mitral valve integrity. DISCUSSION: This case demonstrates the value of integrated imaging techniques in differentiating pseudoinvasive cardiac myxomas from malignant tumors, thereby enhancing diagnostic approaches for ventricular masses. TAKE-HOME MESSAGES: Multimodal imaging is crucial for diagnosing cardiac tumors located in atypical regions. Recognizing benign pseudoinvasive patterns is key to avoiding unnecessary radical surgery.
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Liu et al. (2025) conducted a case report in Papillary muscle-origin left ventricular myxoma with pseudoinvasive growth (n=1). Multimodal imaging-guided subtotal surgical resection (echocardiography, CT, 3.0-T CMR, and 18F-FDG PET/CT) was evaluated on Tumor recurrence and mitral valve integrity. Multimodal imaging-guided subtotal resection of a pseudoinvasive left ventricular myxoma preserved mitral valve function (LVEF 60%-65%) with no recurrence over 23 months.
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