Imines in Stille‐Type Cross‐Coupling Reactions: A Multicomponent Synthesis of α‐Substituted Amides

An alternative to nucleophilic chemistry for the construction of α-substituted amides and amine derivatives from imines is provided by the Stille-type coupling of imines with organotin reagents and acid chlorides (see scheme). This Pd-catalyzed reaction is suitable for components with a range of functional groups and has been extended into a four-component-coupling reaction with carbon monoxide. dba=dibenzylideneacetone, RT=room temperature. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52123_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.