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Explores the effect of metAB on methionine metabolism and colonization in Campylobacter jejuni, indicating its significance in pathogen-host interactions.
Campylobacter jejuni is a zoonotic pathogen and is one of the leading causes of human gastroenteritis worldwide. C. jejuni IA3902 (representative of the sheep abortion clone) is genetically similar to C. jejuni W7 (representative of strain type NCTC 11168); however, there are significant differences in the ability of luxS mutants of these strains to colonize chickens. LuxS is essential for the activated methyl cycle and generates homocysteine for conversion to l -methionine.
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Ruddell et al. (2020) studied this question.
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