Key result
A combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in Wistar rats.
Why the study?
Following evidence of its antioxidant and anti-hyperglycemic potential, the authors sought to investigate the cardioprotective effects of a combined formulation of grape seed extract and Zincovit tablets against ischemia-reperfusion injury.
Does a combined formulation of grape seed extract and Zincovit tablets protect against myocardial ischemia-reperfusion injury in Wistar rats?
Does a combined formulation of grape seed extract and Zincovit tablets protect against myocardial ischemia-reperfusion injury in Wistar rats?
A combined formulation of grape seed extract and a multivitamin-mineral supplement showed cardioprotective antioxidant effects in a rat model of myocardial ischemia-reperfusion injury.
Hypothesis-generating for combined grape seed extract formulations in cardioprotection; leaves open translation to human ischemia-reperfusion injury.
Zincovit tablets have been used as nutritional food supplement over a prolonged period of time. In previous studies, we had reported combined formulation of grape seed extract and Zincovit tablets for its strong in-vitro, in-vivo antioxidant, anti-hyperglycemic and anti-cataractogenic potential. Consequently, the aim of the present study was to investigate the cardio-protective effect of single combined formulation of grape seed extract and Zincovit tablets using a Langendorff model of ischemia-reperfusion in Wistar rats. Combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in terms of increased coronary flow rate, decreased creatine kinase activity in coronary effluent, decreased MDA, 4-HNE and increased protein thiol content in heart tissue homogenate. The present study revealed that the combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against myocardial ischemia-reperfusion injury in Wistar rats.
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Satyam et al. (2023) studied Myocardial ischemia-reperfusion injury. Combined formulation of grape seed extract and Zincovit tablets was evaluated on Cardiac injury (coronary flow rate, creatine kinase activity, MDA, 4-HNE, protein thiol content). A combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in Wistar rats.
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