Athletic amenorrhea in female runners was associated with reduced endothelium-dependent brachial artery dilation (1.08%) vs oligomenorrheic (6.44%) and eumenorrheic (6.38%) controls (P<0.05).
Observational (n=32)
Is athletic amenorrhea associated with reduced endothelium-dependent brachial artery dilation in young female runners?
Athletic amenorrhea in young female runners is associated with reduced endothelium-dependent dilation, suggesting early signs of cardiovascular risk.
Absolute Event Rate: 1.08% vs 6.38%
p-value: p=< 0.05
PURPOSE: To test the hypothesis that young females with athletic amenorrhea and oligomenorrhea show signs of early cardiovascular disease manifested by decreased endothelium-dependent dilation of the brachial artery. METHODS: Ten women with athletic amenorrhea (mean +/- SE, age 21.9 +/- 1.2 yr), 11 with oligomenorrhea (age 20.8 +/- 1.1 yr), and 11 age-matched controls (age 20.2 +/- 1.1 yr) were studied. Study subjects were amenorrheic an average of 2.3 (range 0.6-5) yr and oligomenorrheic an average of 6.2 yr. All ran a minimum of 25 miles.wk. They were nonpregnant and free of metabolic disease. Brachial artery flow-mediated dilation (endothelium-dependent) was measured with a noninvasive ultrasound technique in each group. RESULTS: Endothelium-dependent brachial artery dilation was reduced in the amenorrheic group (1.08 +/- 0.91%) compared with oligomenorrheic (6.44 +/- 1.3%; P< 0.05) and eumenorrheic (6.38 +/- 1.4%; P< 0.05) groups. CONCLUSION: Athletic amenorrhea is associated with reduced endothelium-dependent dilation of the brachial artery. This may predispose to accelerated development of cardiovascular disease.
Hoch et al. (Sat,) conducted a observational in Athletic amenorrhea (n=32). Athletic amenorrhea vs. Oligomenorrhea and eumenorrhea was evaluated on Endothelium-dependent brachial artery dilation (p=< 0.05). Athletic amenorrhea in female runners was associated with reduced endothelium-dependent brachial artery dilation (1.08%) vs oligomenorrheic (6.44%) and eumenorrheic (6.38%) controls (P<0.05).