To develop and evaluate a Carbopol-based hydrogel containing Moringa oleifera root extract for antioxidant and antimicrobial diabetic wound management

Background: Diabetic wounds are characterized by oxidative stress and infection, leading to delayed healing. Objective: To develop a Carbopol-based hydrogel incorporating Moringa oleifera root extract. Methods: Hydrogel formulations (F1–F6) were prepared and evaluated for physicochemical properties, drug release, antioxidant and antimicrobial activity. Results: Batch F4 showed optimal pH (6.2), viscosity (15800 cP), and 98% drug release within 6 hours. Release followed Korsmeyer–Peppas kinetics (R² = 0.9864), indicating non-Fickian diffusion. The formulation exhibited significant antioxidant (~70%) and antimicrobial activity (24 mm zone). Conclusion: The developed hydrogel demonstrates strong potential for diabetic wound management.