Lipid-sensing GPCRs in Cardiometabolic Diseases: Emerging Roles for GPR84

Cardiometabolic diseases are characterized by the integration of metabolic imbalance, chronic inflammation, and vascular dysfunction.Lipid-sensing G protein-coupled receptors (GPCRs) have emerged as important molecular mediators that translate nutrient cues into coordinated metabolic and inflammatory responses.While several lipid-responsive GPCRs have been implicated in metabolic regulation, their roles in inter-organ communication between adipose tissue and the vasculature remain incompletely understood.GPR84, originally characterized in immune cells, is increasingly recognized as a receptor expressed in metabolically active adipose depots.Emerging evidence suggests that GPR84 may contribute to the maintenance of adipose metabolic function and influence adipose-derived signals that affect vascular homeostasis.By integrating lipid sensing with adipose tissue biology, GPR84 may represent a regulatory node linking metabolic stress to atherosclerotic progression.Further clarification of its tissue-specific functions may provide new insights into the pathophysiology of cardiometabolic disease and identify potential therapeutic opportunities.