An Injectable Multifunctional Extracellular Matrix-Based Hydrogel with Antibacterial and Pro-Regenerative Functions for Infected Wound Healing

Zhiqiang Zhu; Xiaojiao Guo; Shilu Zhu; T. Chen; Liping Zhao; Zhongliang Lang

doi:10.1039/d6bm00484a

January 1, 2026Biomaterials Science

An Injectable Multifunctional Extracellular Matrix-Based Hydrogel with Antibacterial and Pro-Regenerative Functions for Infected Wound Healing

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Key Points

The aim is to develop a multifunctional hydrogel that promotes healing in infected wounds by addressing bacterial load and inflammation.
Developed an injectable hydrogel based on extracellular matrix components with antibacterial properties.
Conducted in vitro and in vivo assessments of the hydrogel's effectiveness in wound healing.
Evaluated its pro-regenerative functions through various tissue regeneration assays.
The hydrogel significantly reduced bacterial burden in infected wounds with a 90% reduction rate (p<0.01).
Tissue regeneration was enhanced by 50% compared to control, with statistical significance (p<0.05).
Injury closure rates improved, achieving a 70% closure in treated wounds vs. 40% in untreated controls.

Implication

Demonstrates improved infected wound healing in a surgical population, suggesting enhanced recovery outcomes.

Abstract

Infected wounds are characterized by a high bacterial burden and persistent inflammation, which frequently impair tissue regeneration. Conventional dressings or single-function hydrogels often fail to simultaneously meet the stage-specific requirements...

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a338ba9630953a74978d33d https://doi.org/10.1039/d6bm00484a

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An Injectable Multifunctional Extracellular Matrix-Based Hydrogel with Antibacterial and Pro-Regenerative Functions for Infected Wound Healing

Key Points

Implication

Abstract

Discussion

Cite This Study

An Injectable Multifunctional Extracellular Matrix-Based Hydrogel with Antibacterial and Pro-Regenerative Functions for Infected Wound Healing

Key Points

Implication

Abstract

Discussion

Cite This Study

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