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June 18, 2026Current Reviews in Clinical and Experimental Pharmacology

Exploring TRPM7 Channel-Kinase for Disease Modulation: A Translational Approach

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Authors

IMIshita MitraPCPriyanka ChakrabortySCSailee Chowdhury

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Overview

Review evaluates TRPM7 as a therapeutic target in diverse diseases, suggesting its selective modulation could improve outcomes.

Key Points

  • This review examines the role of TRPM7 in human diseases and its potential as a therapeutic target.
  • Survey of literature from 2010 to 2025 using major biomedical databases.
  • Synthesis of evidence from molecular, cellular, experimental, and clinical studies focusing on TRPM7.
  • Assessment of TRPM7's influence on cell proliferation, migration, apoptosis, and immune signaling.
  • TRPM7 regulates intracellular Mg2+ and Ca2+ homeostasis, impacting multiple signaling pathways.
  • Aberrant TRPM7 activity is linked to malignancy, neurodegeneration, cardiovascular dysfunction, and autoimmune disease.
  • Pharmacological modulation of TRPM7 shows beneficial effects in preclinical models.

Cite This Study

Mitra et al. (2026) studied this question.

synapsesocial.com/papers/6a338cc3630953a74978defahttps://doi.org/10.2174/0127724328432668260302192316
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