Monitoring Dehydration-Driven Motional Dynamics in Cortical Bone by Employing Solid-State NMR Methodologies

P spin-lattice relaxation measurements serve as highly sensitive indicators of structural and dynamical changes in the hydroxyapatite phase, with potential implications for the early detection of pathological conditions such as osteoporosis. Collectively, this work addresses critical gaps in understanding how dehydration influences the molecular structure and nuclear spin dynamics in organic protein components and inorganic hydroxyapatite components of bone. Additionally, this detailed information about the local electronic environment and nuclear spin dynamics of carbon and phosphorus nuclei will illuminate the path to designing biomimetic bone-like materials.