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June 18, 2026Chemistry - A European Journal

Lysosome‐Targeting Chimeras (LYTACs): From Modular Design Principles to Diverse Therapeutic Applications

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Authors

ZZZhihui ZhouXiamen UniversityQNQ NiuUniversiti Sains MalaysiaXYXiyuan YuXiamen University

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Implication

Review demonstrates the potential of lysosome-targeting chimeras in targeting extracellular proteins, emphasizing design and applications.

Key Points

  • This review aims to explain the design principles and therapeutic potential of lysosome-targeting chimeras (LYTACs).
  • Examined molecular architecture and mechanism of action of LYTACs
  • Systematically analyzed the diversity of protein-of-interest binders and lysosomal targeting receptors
  • Discussed strategies for improving efficiency and clinical relevance
  • LYTACs can selectively degrade extracellular proteins, expanding the utility of targeted protein degradation
  • Diverse protein binders enhance the targeting capability and specificity of LYTACs
  • Identified key challenges and design strategies for effective clinical translation of LYTAC technologies

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a338cf6630953a74978e13dhttps://doi.org/10.1002/chem.71255
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