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Commentary highlights the structure of the octameric resistosome in plants, suggesting insights into immunity mechanisms.
This commentary spotlights landmark work from Guo et al. resolving the structure of the octameric resistosome formed by the active CCG10-nucleotide-binding leucine-rich repeat (NLR) immune receptor WAI3, which triggers sustained, multi-phasic Ca2+ influx. This fills a major knowledge gap regarding EDVID-lacking plant NLRs and provides insight into plant effector-triggered immunity.
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Sun et al. (2026) studied this question.
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