Hydrosilylation of ω-hydroxyalkenes catalysed with 2-methacryloyloxyethyl-phosphorylcholine-protected ruthenium nanoparticles

Mana Yamamoto; Yuuki Tanioka; Sakiko Miyamoto; Mizuho Fujisawa; Tatsuki Nagata; Yuki Kimura; Kazuki Tabaru; Honami Iguchi; Takeyuki Suzuki; Takashi Toyao; Zen Maeno; Ken‐ichi Shimizu; Takeshi Watanabe; Yasuhiko Iwasaki; Yasushi Obora

doi:10.1039/d6cc01831a

January 1, 2026Chemical Communications

Hydrosilylation of ω-hydroxyalkenes catalysed with 2-methacryloyloxyethyl-phosphorylcholine-protected ruthenium nanoparticles

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Key Points

This research aims to explore the selective hydrosilylation of ω-hydroxyalkenes using ruthenium nanoparticles.
Utilized MPC-protected ruthenium nanoparticles for hydrosilylation reactions.
Focused on preventing O-silylation to achieve C=C functionalization.
Conducted direct comparisons with other Ru catalysts.
Achieved selective hydrosilylation not possible with traditional Ru catalysts.
Successfully prevented unwanted O-silylation, increasing reaction efficiency.
Demonstrated unprecedented C=C functionalization capability.

Implication

Demonstrates selective hydrosilylation outcomes in novel hydrosilylation catalysts, suggesting improved functionalization methods.

Abstract

Selective hydrosilylation of ω-hydroxyalkenes is achieved using 2-methacryloyloxyethyl phosphorylcholine (MPC)-protected ruthenium nanoparticles ((PC-SH) Ru NPs). The MPC-derived surface suppresses O-silylation, enabling unprecedented C=C functionalisation unattainable with other Ru catalysts. (PC-SH)...

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Cite This Study

Yamamoto et al. (2026) studied this question.

synapsesocial.com/papers/6a338de8630953a74978eb9b https://doi.org/10.1039/d6cc01831a

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Hydrosilylation of ω-hydroxyalkenes catalysed with 2-methacryloyloxyethyl-phosphorylcholine-protected ruthenium nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

Hydrosilylation of ω-hydroxyalkenes catalysed with 2-methacryloyloxyethyl-phosphorylcholine-protected ruthenium nanoparticles

Key Points

Implication

Abstract

Discussion

Cite This Study

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