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Investigates glucose activation of β-glucosidase in Bacillus subtilis, suggesting roles of glycolytic changes and soybean broth components.
This study investigated the mechanisms of glucose-induced β-glucosidase (Bgl) activation in Bacillus subtilis strains 168 and Miyagino. Distinct Bgl-related genes were upregulated by glucose in the two strains. These increases were suppressed in the ΔpfkA and ΔfbaA mutants, but not Δpyk, mutant, suggesting the involvement of upper glycolytic flux changes. Additionally, we found that soybean broth medium may contain non-sugar Bgl-activating factors.
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Shyuichiro Inagaki (2026) studied this question.
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