Selective Magnetic Particle Imaging of CD44 Expressing Cells Using Iron Oxide Nanoprobes Functionalized with Chemically Modified Hyaluronan

Q: What does this research mean for the field?

Iron oxide nanoprobes functionalized with chemically modified hyaluronan enable selective magnetic particle imaging of CD44-expressing cells. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mohammad H. El‐Dakdouki; Chia-Wei Yang; A. K. M. Atique Ullah; Fei Fang; Kunli Liu; Baraah U Hijazi; Xuefei Huang

doi:10.1039/d5na00979k

January 1, 2026Nanoscale AdvancesOpen Access

Selective Magnetic Particle Imaging of CD44 Expressing Cells Using Iron Oxide Nanoprobes Functionalized with Chemically Modified Hyaluronan

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Key Points

This research aims to enhance the selective binding of hyaluronan to CD44 expressing cells using iron oxide nanoprobes.
Utilized iron oxide nanoparticles functionalized with chemically modified hyaluronan.
Investigated the binding efficacy to CD44 expressing cells.
Assessed the imaging capabilities of the modified nanoparticles.
Demonstrated enhanced binding of HA-functionalized nanoparticles to CD44 expressing cells.
Achieved effective imaging of cells, indicating potential for targeted therapeutic applications.

Implication

Explores selective imaging of CD44 expressing cells using hyaluronan-functionalized nanoparticles, suggesting improved targeting.

Abstract

Hyaluronan (HA) is a naturally occurring biocompatible and non-immunogenic linear anionic glycosaminoglycan. In an attempt to enhance the selective binding of HA to the cluster of differentiation 44 (CD44), we...

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Cite This Study

El‐Dakdouki et al. (2026) studied this question.

synapsesocial.com/papers/6a338e14630953a74978ec82 https://doi.org/10.1039/d5na00979k

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Selective Magnetic Particle Imaging of CD44 Expressing Cells Using Iron Oxide Nanoprobes Functionalized with Chemically Modified Hyaluronan

Key Points

Implication

Abstract

Discussion

Cite This Study

Selective Magnetic Particle Imaging of CD44 Expressing Cells Using Iron Oxide Nanoprobes Functionalized with Chemically Modified Hyaluronan

Key Points

Implication

Abstract

Discussion

Cite This Study

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