Elevated plasma monounsaturated fatty acids and their associations with disease activity, adiposity and sex in patients with rheumatoid arthritis: a cross-sectional study
Cross-sectional study explores the relationship of MUFAs with disease activity and body fat in rheumatoid arthritis, indicating implications for treatment.
Key Points
This study aims to investigate the associations between monounsaturated fatty acids and disease activity in rheumatoid arthritis patients.
Cross-sectional study involving 52 individuals with rheumatoid arthritis and 30 matched controls.
Assessment of disease activity using the DAS28-CRP and body composition measurements.
Plasma fatty acids measured by gas chromatography and dietary intake recorded via a 4-day food journal.
Patients with RA had lower insulin sensitivity, higher triglycerides, and lower physical activity levels.
Oleic acid associated with RA status (β=1.4; 95% CI 0.33 to 2.5) and waist-to-hip ratio (β=14; 95% CI 6.9 to 21).
Higher oleic and gondoic acids correlated with DAS28-CRP in RA patients, while palmitoleic acid was higher in women but not linked to DAS28-CRP.