Study achieved high diastereoselectivity in synthesizing luminacin D, indicating significant advances in stereochemistry.
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes that possess a non-chelating α-ether substituent, even if the α-position is a quaternary centre and/or a spiro-epoxide. This reaction was used as a key step in an enantioselective synthesis of the angiogenesis inhibitor luminacin D.
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Bartlett et al. (2014) studied this question.
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