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April 1, 1986Journal of Medicinal Chemistry

Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac

Angel Gusman Francisco Yuste Rubén A. Toscano J.M. Young

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Abstract

The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.

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Gusman et al. (1986) studied this question.

synapsesocial.com/papers/6a33b952564550b2400e87ea https://doi.org/10.1021/jm00154a027

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