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November 1, 1984Journal of Medicinal ChemistryOpen Access

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs

David A. Walsh H. W. MORAN Dwight A. Shamblee Ibrahim M. Uwaydah William J. Welstead Lawrence F. Sancilio Warren N. Dannenburg

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Abstract

A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.

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Walsh et al. (1984) studied this question.

synapsesocial.com/papers/6a33b952daadf05dbea733c9 https://doi.org/10.1021/jm00377a001

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