Key result
Emergency physician clinical judgment outperforms Wells and Revised Geneva scores for diagnosing suspected PE.
Why the study?
Common presenting symptoms of pulmonary embolism lack sensitivity and specificity, requiring clinical probability assessment. The study aimed to compare emergency physicians' clinical judgment with the Wells and Revised Geneva scores in predicting PE in suspected cases.
Does emergency physicians' clinical judgment improve the diagnostic prediction of pulmonary embolism compared to the Wells and Revised Geneva scores in patients presenting to the emergency department with suspected PE?
Observational (n=248)
Single-blind
Yes
Does emergency physicians' clinical judgment improve the diagnostic prediction of pulmonary embolism compared to the Wells and Revised Geneva scores in patients presenting to the emergency department with suspected PE?
Absolute Event Rate: 0.834% vs 0.766%
Emergency physicians' unstructured clinical judgment demonstrated a numerically higher diagnostic accuracy (AUC 0.834) for suspected pulmonary embolism than the structured Wells and Revised Geneva scores.
Clinical judgment may outperform PE scores in ED diagnosis; leaves open need for prospective validation before practice change.
Shortness of breath and chest pain are the most common presenting symptoms of pulmonary embolism (PE); however, these findings lack both sensitivity and specificity. Therefore, clinical probability assessment remains a key component in the diagnostic evaluation of suspected PE. Clinical prediction rules such as the Wells and Revised Geneva scores are widely used to estimate pre-test probability. This study aimed to compare emergency physicians’ clinical judgment with the Wells and Revised Geneva scores in predicting pulmonary embolism in patients presenting to the emergency department with suspected PE. This prospective dual-center study included patients presenting to the emergency departments of two tertiary care hospitals with suspected PE. The evaluating emergency physician first assessed the clinical probability of PE (low, intermediate, or high) based solely on clinical judgment. Subsequently, the Wells and Revised Geneva scores were calculated independently by a second physician who was blinded to the initial clinical assessment. The diagnostic performance of clinical judgment, Wells score, and Revised Geneva score was evaluated using receiver operating characteristic (ROC) curve analysis. A total of 248 patients with suspected PE were included in the study. Pulmonary embolism was confirmed in 38 patients (15.3%). Clinical judgment showed a numerically higher AUC compared with both the Wells and Revised Geneva scores. The area under the ROC curve (AUC) was 0.834 for clinical judgment, 0.766 for the Wells score, and 0.757 for the Revised Geneva score. In patients presenting with suspected pulmonary embolism, emergency physicians clinical judgment showed favorable diagnostic discrimination and a numerically higher AUC than the Wells and Revised Geneva scores. These findings suggest that clinical assessment remains a valuable component of the diagnostic approach to suspected PE.
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Şaşmaz et al. (2026) conducted an observational in Suspected pulmonary embolism (n=248). Clinical judgment vs. Wells score and Revised Geneva score was evaluated on Diagnostic performance (AUC) for predicting pulmonary embolism. Emergency physicians' clinical judgment demonstrated a higher diagnostic discrimination for suspected pulmonary embolism (AUC 0.834) compared to the Wells score (AUC 0.766) and Revised Geneva score (AUC 0.757).
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