Key result
Integrated CTA and perfusion accurately detects flow-limiting CAD with an AUC of ~0.87.
Why the study?
Does integrated CTA-CTP accurately identify flow-limiting CAD compared to ICA and SPECT/MPI in patients undergoing coronary angiography?
Cross-Sectional (n=381)
Blinded independent core laboratories
Yes
Does integrated CTA-CTP accurately identify flow-limiting CAD compared to ICA and SPECT/MPI in patients undergoing coronary angiography?
Effect estimate: AUC 0.87 (95% CI 0.84-0.91)
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The integration of CTA and CTP provides high diagnostic accuracy for identifying flow-limiting coronary artery disease, significantly improving upon CTA alone.
Rochitte et al. (2013) conducted a cross-sectional in Coronary artery disease (n=381). Integrated computed tomography angiography (CTA) and CT myocardial perfusion (CTP) vs. Invasive coronary angiography (ICA) with stress SPECT/MPI was evaluated on Patient-based diagnostic accuracy (AUC) for detecting or excluding flow-limiting CAD (AUC 0.87, 95% CI 0.84-0.91). Integrated computed tomography angiography and perfusion accurately identified patients with flow-limiting coronary artery disease with an AUC of 0.87 (95% CI 0.84-0.91).
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