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June 19, 2026Ageing Research Reviews0 citationsOpen Access

Macrophages Regulate Extracellular Matrix Remodeling in Aging Skeletal Muscle

Macrophage regulation of extracellular matrix remodeling in aging skeletal muscle

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Authors

CCChang-Yi CuiJNJoseph C. NazarioISIsabelle A. Stephen

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Overview

This review examines macrophage influence on extracellular matrix changes in skeletal muscle, highlighting the implications for aging and regeneration.

Key Points

  • To explore the role of macrophages in regulating extracellular matrix remodeling in aging skeletal muscle.
  • Review current literature on ECM production and remodeling in skeletal muscle.
  • Emphasize the role of macrophages, particularly COL+ macrophages, in this process.
  • Aging skeletal muscle undergoes significant ECM remodeling regulated by macrophages.
  • COL+ macrophages play a crucial role in the dynamics of ECM production and remodeling in aging muscle.
  • The function of these macrophages in maintaining muscle homeostasis and promoting regeneration remains poorly understood.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a34dc0f65a5b0777af2c861https://doi.org/10.1016/j.arr.2026.103208
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