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June 19, 2026BiologyOpen Access

Investigating the Shared Mechanisms of Endocrine-Disrupting Chemicals in Urogenital Tumors

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Authors

CLcundong LiuSWShenghao WuRZRanran Zhou

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Overview

Randomized trial investigates shared molecular mechanisms of EDCs in urogenital tumors, suggesting new therapeutic targets.

Key Points

  • This research aimed to identify the common molecular mechanisms of endocrine-disrupting chemicals (EDCs) in urogenital cancers.
  • Analyzed 12 prevalent EDCs across four urogenital cancers using network toxicology and protein–protein interaction analysis.
  • Conducted molecular docking and dynamics simulations to assess binding affinities to core tumor targets.
  • Utilized TCGA data to correlate CASP9 expression with overall survival in renal cell carcinoma patients.
  • EGFR and CASP3 were identified as key targets in bladder cancer, while CASP9 was linked to poorer survival in renal cell carcinoma (HR not specified).
  • Molecular docking showed BaP strong affinity for CASP9 (ΔG = −9.8 kcal/mol).
  • Chronic BaP exposure increased protein stability of CASP9 without affecting its mRNA expression in cell lines.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a34dde465a5b0777af2d787https://doi.org/10.3390/biology15120946
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