Robust Pt nanozyme for visual isoniazid determination in commercial tablets and biosamples

Lili Ai; Qi Zhang; Chenwang Zhang; Zhi Xia; Xiaoxu Cao; Yizhou Xu; Phouphien Keoingthong; Shengkai Li

doi:10.1039/d6ay00345a

January 1, 2026Analytical Methods

Robust Pt nanozyme for visual isoniazid determination in commercial tablets and biosamples

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Key Points

This research aims to develop a reliable biosensor for determining isoniazid levels for enhanced tuberculosis treatment.
Developed a colorimetric biosensor utilizing a platinum nanozyme as a peroxidase mimic.
Tested the biosensor on commercial tablets and biological samples for isoniazid detection.
Evaluated the method's reliability and accuracy in quantifying isoniazid levels.
Successfully quantified isoniazid in commercial tablets with a high degree of accuracy.
Achieved effective detection limits suitable for clinical and commercial applications.
Demonstrated the potential for personalized therapy through reliable monitoring of isoniazid levels.

Implication

Demonstrates effective isoniazid quantification in biosamples, suggesting a method for personalized tuberculosis therapy.

Abstract

A reliable method for isoniazid (INH) determination is critical for personalized tuberculosis therapy. In this study, we developed a robust colorimetric biosensor using a peroxidase (POD)-like platinum nanozyme (Pt-NZ) as...

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Cite This Study

Ai et al. (2026) studied this question.

synapsesocial.com/papers/6a34de1265a5b0777af2d881 https://doi.org/10.1039/d6ay00345a

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Robust Pt nanozyme for visual isoniazid determination in commercial tablets and biosamples

Key Points

Implication

Abstract

Discussion

Cite This Study

Robust Pt nanozyme for visual isoniazid determination in commercial tablets and biosamples

Key Points

Implication

Abstract

Discussion

Cite This Study

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