Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow StromalCells

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Human cancer and bone marrow stromal cells cultured in 3D spheroids exhibit significantly lower sensitivity to cisplatin compared to conventional 2D monolayers due to hampered drug penetration and differences in cell proliferation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ceri-Anne Suurmond; Z Wang; Jose Kooloos; Sterre Andriessen; Sander Leeuwenburgh; Jeroen van den Beucken

doi:10.2174/0115680096481806260605115025

June 12, 2026Current Cancer Drug Targets

Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow StromalCells

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Key Points

The study aims to compare cisplatin sensitivity between conventional 2D monolayers and biomaterial-free 3D spheroid cultures.
Evaluated cisplatin sensitivity in human cancer cell lines (PC3, MDA-MB-231) and human bone marrow stromal cells in 2D and 3D models.
Conducted proliferation and viability assays to assess cytotoxicity of cisplatin.
Analyzed effects of acute versus continuous cisplatin exposure on cellular behavior and drug sensitivity correlation with cell doubling time.
3D spheroid cultures displayed significantly lower sensitivities to cisplatin compared to 2D cultures.
Cisplatin penetration into the core of 3D spheroids was time- and concentration-dependent, affecting drug sensitivity.
Cisplatin sensitivity correlated with cell doubling time across all tested cell types.

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Implication

Compares cisplatin sensitivity in 2D and 3D cultures of cancer cells, highlighting model dimensionality impacts.

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Cite This Study

Suurmond et al. (2026) studied this question.

synapsesocial.com/papers/6a34def565a5b0777af2e3fa https://doi.org/10.2174/0115680096481806260605115025

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Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow StromalCells

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow StromalCells

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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