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June 19, 2026Current Cancer Drug Targets

Comparing Cisplatin Sensitivity in Conventional 2D Versus Biomaterialfree 3D Spheroid Cultures of Human Cancer and Bone Marrow StromalCells

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Authors

CSCeri-Anne SuurmondZWZ WangJKJose Kooloos

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Overview

Randomized trial compares cisplatin sensitivity in 2D and 3D cultures of cancer cells, highlighting model dimensionality impacts.

Key Points

  • The study aims to compare cisplatin sensitivity between conventional 2D monolayers and biomaterial-free 3D spheroid cultures.
  • Evaluated cisplatin sensitivity in human cancer cell lines (PC3, MDA-MB-231) and human bone marrow stromal cells in 2D and 3D models.
  • Conducted proliferation and viability assays to assess cytotoxicity of cisplatin.
  • Analyzed effects of acute versus continuous cisplatin exposure on cellular behavior and drug sensitivity correlation with cell doubling time.
  • 3D spheroid cultures displayed significantly lower sensitivities to cisplatin compared to 2D cultures.
  • Cisplatin penetration into the core of 3D spheroids was time- and concentration-dependent, affecting drug sensitivity.
  • Cisplatin sensitivity correlated with cell doubling time across all tested cell types.

Cite This Study

Suurmond et al. (2026) studied this question.

synapsesocial.com/papers/6a34def565a5b0777af2e3fahttps://doi.org/10.2174/0115680096481806260605115025
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