What question did this study set out to answer?

This review aims to explore the role of the endocannabinoid system in the regulation of depression and its potential as a therapeutic target.

Mechanism of endocannabinoid system activation in regulating depression

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Review summarizes how endocannabinoid system activation influences mood in depression, suggesting new treatment avenues.

This review aims to explore the role of the endocannabinoid system in the regulation of depression and its potential as a therapeutic target.
Summarized existing evidence on ECS alterations in depression.
Discussed mechanisms of ECS activation in alleviating depressive symptoms.
Reviewed both pharmacological and non-pharmacological interventions affecting the ECS.
ECS can suppress neuroinflammation by regulating microglial activation and cytokine release.
ECS signaling supports hypothalamic-pituitary-adrenal axis homeostasis, with altered FAAH-AEA-CB1 pathways impacting stress responses.
ECS activation interacts with brain-derived neurotrophic factor pathways to enhance neuroplasticity.

LIU et al. (2026) studied this question.

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