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Planar-chiral ferrocenes are widely applied in catalytic asymmetric transformations in scientific research as well as in industry. A plethora of different methodologies have been developed to access these molecules with a high degree of regio- and stereoselectivity. The aim of this contribution is to give a comprehensive overview of this topic. The synthesis of 1,2- and 1,3-substituted ferrocenes by electrophilic aromatic substitution, ortho-directed metalation, kinetic resolution, and desymmetrization is discussed. Advantages and disadvantages are highlighted.
Schaarschmidt et al. (Wed,) studied this question.
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