Multiple grasping attempts (≥8) during M-TEER using the PASCAL system were safe, with 0% device-related complications in both high and low attempt groups.
Cohort (n=391)
No
Does a high number of grasping attempts (≥8) during M-TEER with the PASCAL system adversely affect safety and procedural outcomes compared to fewer attempts (≤7) in patients with severe MR?
Multiple grasping attempts during M-TEER with the PASCAL system are safe, do not increase device-related complications, and result in sustained MR reduction comparable to procedures requiring fewer attempts.
Absolute Event Rate: 0% vs 0%
BACKGROUND: Multiple grasping attempts are routinely required during mitral valve transcatheter-edge-to-edge repairs (M-TEER) to achieve optimal leaflet capture and minimize mitral regurgitation (MR). Whether extensive grasping adversely affects procedural outcomes remains unknown. AIMS: We aimed to evaluate safety, procedural characteristics and durability of MR reduction in M-TEER procedures with low vs. high number of grasping attempts using the PASCAL system. METHODS: Consecutive patients with severe MR who underwent M-TEER using the PASCAL system between 2019 and 2024 at our center were analyzed. Procedures were stratified according to grasping attempts: ≤7 (≤80th percentile, median 4 2;5) vs. ≥8 (>80th percentile, median 10 9;12, max. 22). Baseline, procedural, short- and latest outcomes, were compared between groups. RESULTS: Overall, 391 M-TEER procedures (mean age 77.7 ± 10.1 years, 57.5% male) were included. No single leaflet device attachment, leaflet injury or other device-related complication occurred in either group. Procedures with ≥8 attempts were longer (126 ± 47.6 min vs. 82.9 ± 43.3 min; p < 0.001) and associated with larger baseline EROA (0.48 0.38;0.70 vs. 0.40 0.30;0.50 cm CONCLUSION: Multiple grasping during M-TEER using the PASCAL system is safe and results in sustained MR reduction, high procedural success and latest outcomes comparable to procedures requiring fewer attempts.
Jürgens et al. (Mon,) conducted a cohort in Severe mitral regurgitation (n=391). High number of grasping attempts (≥8) vs. Low number of grasping attempts (≤7) was evaluated on Device-related complications (single leaflet device attachment, leaflet injury, or other). Multiple grasping attempts (≥8) during M-TEER using the PASCAL system were safe, with 0% device-related complications in both high and low attempt groups.
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