Key result
Active patients with lamin A/C genotype had lower left ventricular ejection fraction compared with sedate patients (43% vs 51%, P=0.006), with a 4% decrease per tertile increment in lifetime exercise.
Why the study?
Competitive sports have been associated with adverse events in lamin A/C cardiomyopathy, but data on recreational exercise are lacking.
Does higher lifetime exercise exposure worsen left ventricular systolic function in patients with lamin A/C genotype?
Population
69 lamin A/C genotype positive patients
Comparison
Active vs sedate based on lifetime exercise hours above or below median
Design
Observational questionnaire-based study
Authors
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LVEF decline with higher lifetime exercise should not yet change activity guidance; leaves open causality and requires prospective confirmation.
Observational (n=69)
Does higher lifetime exercise exposure worsen left ventricular systolic function in patients with lamin A/C genotype?
Mean Difference: -4 (95% CI -7–-0.4)
Absolute Event Rate: 43% vs 51%
p-value: p=0.03
Higher cumulative lifetime exercise is associated with worse left ventricular systolic function and earlier onset of impairment in patients with lamin A/C genotype.
Skjølsvik et al. (2020) conducted an observational in Lamin A/C genotype (n=69). Lifetime exercise (active) vs. Sedate (lifetime exercise below median) was evaluated on Left ventricular ejection fraction (MD -4%, 95% CI -7 to -0.4, p=0.03). Active patients with lamin A/C genotype had lower left ventricular ejection fraction compared with sedate patients (43% vs 51%, P=0.006), with a 4% decrease per tertile increment in lifetime exercise.