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June 20, 2026Discover OncologyOpen Access

CLIP2::MET fusion identifies a molecularly distinct glioneuronal tumor

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Authors

JFJawad FaresJAJared T. AhrendsenHCHarrshavasan T. Congivaram

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Overview

Case report identifies CLIP2::MET fusion in a glioneuronal tumor, suggesting implications for targeted therapy.

Key Points

  • The aim is to characterize a distinct molecular alteration in a rare glioneuronal tumor to enhance diagnosis and treatment options.
  • Histology and standard molecular testing were performed on a tumor from a 19-year-old female.
  • DNA methylation profiling and next-generation RNA sequencing were utilized to identify genetic alterations.
  • CLIP2::MET fusion was specifically examined as a potential driver mutation.
  • Histological analysis showed mixed glial and neuronal elements with low proliferative activity.
  • Standard molecular testing revealed no IDH1/IDH2 or BRAF mutations.
  • RNA sequencing identified a CLIP2::MET fusion, indicating a unique molecular profile relevant to precision oncology.

Cite This Study

Fares et al. (2026) studied this question.

synapsesocial.com/papers/6a362d9ddb0793dc1a535c26https://doi.org/10.1007/s12672-026-05421-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion2024 · 4 citations
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