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June 20, 2026iScienceOpen Access

Tandem single-cell epigenetic and transcriptomic analysis reveals spatiotemporally distinct genomic features among testis cell lineages

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Authors

MRMustika RahmawatiTHTia M. HoisingtonBLBlanca Lopez-Biladeau

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Overview

Randomized trial investigates genomic features in testis cell lineages, suggesting insights into infertility.

Key Points

  • This research aims to understand how epigenetic states and chromatin maturation guide testis development across different cell lineages.
  • Generated paired single-nucleus chromatin and transcriptomic data from mouse testis cells from embryonic day 14.5 to postnatal day 4.
  • Analyzed chromatin accessibility and transcription factor activity across germline and somatic lineages.
  • Investigated spatial and temporal epigenetic maturation and its impact on cell fate decisions.
  • Epigenetic maturation varied across lineages and was linked to specific chromatin profiles such as accessibility at distal intergenic regions.
  • Sertoli cells exhibited unique chromatin profiles depending on their spatial organization within the seminiferous tubules.
  • Cell-to-cell communication analyses revealed interconnected networks influencing lineage-specific behaviors.

Cite This Study

Rahmawati et al. (2026) studied this question.

synapsesocial.com/papers/6a362e1edb0793dc1a535ff9https://doi.org/10.1016/j.isci.2026.116452
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