Case study shows integrating sustainability metrics enhances quality control decisions in biopharmaceuticals, improving environmental impact.
Key Points
This case study aimed to demonstrate how integrating greenness and whiteness metrics can enhance decision-making in pharmaceutical quality control.
Compared non-aqueous potentiometric titrations (PT) with spectrofluorimetric methods (SFM) for aromatic amino acid assays.
Applied the Advanced National Environmental Methods Index, Analytical Eco-Scale, Green Analytical Procedure Index, and Analytical GREEnness metric for sustainability assessment.
Utilized White Analytical Chemistry to combine analytical performance with sustainability and operational feasibility.
SFM was preferred, indicating lower environmental impact with a higher Eco-Scale score of 93 compared to PT's 76.
AGREE scores showed SFM at 0.61 versus PT at 0.34, highlighting better sustainability metrics.
WAC scores indicated SFM at 81.3 while PT scored only 65.5, confirming SFM as the environmentally and practically superior method.