This Account demonstrates calibration-free sensing technologies for molecular monitoring in clinical settings, indicating promising advancements in biosensing accuracy and longevity.
Key Points
This research addresses the limitations of traditional electrochemical biosensors that require external calibration, aiming to enhance their long-term performance in complex biofluids.
Describes intrinsic dual-signal encoding strategy using two redox-reporters for ratiometric outputs.
Explains operationally programmed self-referencing strategy to extract drift-differentiated kinetics.
Discusses interfacial engineering to reduce signal decay through optimization of molecular components.
The dual-signal strategy produces self-normalized readouts without the need for calibration.
Self-referencing strategy effectively compensates for signal drift in fluctuating environments.
Interfacial engineering demonstrates improved longevity of electrochemical signals in complex settings.