What question did this study set out to answer?

This research aims to explore how protein-disulfide reductase activity influences tumor growth and transplantability.

Tumor Growth and Disulfide Reduction: Possible Dependence on Protein-Disulfide Reductase,

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial examines tumor growth mechanisms in murine models, suggesting disulfide reduction plays a crucial role.

This research aims to explore how protein-disulfide reductase activity influences tumor growth and transplantability.
Inactivated murine tumor cells with sulfhydryl-blocking agents and assessed transplantability.
Evaluated protective effects of various sulfhydryl compounds against inactivation.
Analyzed activity levels of NADPH-dependent protein-disulfide reductase in tumor and normal cells.
All murine tumors lost transplantability after sulfhydryl-blocking procedures, but could be reactivated.
Higher NADPH-dependent protein-disulfide reductase activity was observed in tumor cells compared to normal cells.
Pretreatment with specific compounds increased the immunogenicity of SH-blocked ascites tumors.

Apffel et al. (1973) studied this question.

View Full Paper

Ask AI

Bookmark