What question did this study set out to answer?

The study aims to investigate the association between chromosomal instability and malignancy in porokeratosis of Mibelli.

Chromosomal Instability Associated With Susceptibility to Malignant Disease in Patients With Porokeratosis of Mibelli

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Randomized trial reveals chromosomal instability linked to skin cancer in porokeratosis patients, suggesting enhanced malignancy risk.

The study aims to investigate the association between chromosomal instability and malignancy in porokeratosis of Mibelli.
Skin biopsies from 4 patients with porokeratosis of Mibelli were analyzed.
Fibroblasts were cultured from affected and unaffected skin areas.
Chromosomal abnormalities were assessed in cell lines derived from these fibroblasts.
Chromosomal abnormalities were found in 8 of 16 fibroblast lines from affected areas.
No specific chromosomal abnormalities were common among all patient cell lines.
Control lines from age-matched healthy individuals showed no abnormal clones.

Taylor et al. (1973) studied this question.

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