Poor overall performance of the resmetirom NIT algorithm: a multinational comparison across four tertiary care centers in Germany, Türkiye, and the United States

E Kaya; R. Nadeem; A. Jain; R. Shah; S. Hemant; S. Kahlon; C. Nyguyen; M. Chughtai; R. Vuppalanchi; J. P. Sowa; A. Canbay; Y. Yilmaz; N. Alkhouri

doi:10.3205/26vzmnrw106

June 18, 2026Open Access

Poor overall performance of the resmetirom NIT algorithm: a multinational comparison across four tertiary care centers in Germany, Türkiye, and the United States

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to assess the effectiveness of the resmetirom NIT algorithm for identifying treatment-eligible patients with metabolic dysfunction-associated steatohepatitis.
Conducted at four tertiary care centers in Germany, Türkiye, and the United States.
Utilized a multinational comparison approach to evaluate the algorithm's performance.
Assessed treatment eligibility based on fibrosis stages F2–F3.
Found that the resmetirom NIT algorithm showed poor overall performance across all centers.
Indicated significant discrepancies in treatment eligibility identification based on locale.
Suggested a need for improved methods to assess metabolic dysfunction and steatohepatitis.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Compares resmetirom NIT algorithm effectiveness in identifying eligible patients, indicating need for improvement.

Abstract

Background and objective: Resmetirom was recently approved in Europe as the first pharmacologic therapy for patients with metabolic dysfunction–associated steatohepatitis (MASH) and fibrosis stages F2–F3. Recently, a combination of NITs has been proposed to identify treatment-eligible [for full text, please go to the a.m. URL]

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kaya et al. (2026) studied this question.

synapsesocial.com/papers/6a3630cadb0793dc1a537d58 https://doi.org/10.3205/26vzmnrw106

View Full Paper

Ask AI

Bookmark

Share

Poor overall performance of the resmetirom NIT algorithm: a multinational comparison across four tertiary care centers in Germany, Türkiye, and the United States

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Poor overall performance of the resmetirom NIT algorithm: a multinational comparison across four tertiary care centers in Germany, Türkiye, and the United States

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading