Chiral recognition of 2,3-dihydroxypropanesulfonate by bacterial transport proteins adapted to distinct ecological niches

Helen Barber; Sabrina Borusak; Adam William Endian Stewart; Hamza Tahir; Nichollas Scott; David Shleheck; Mihwa Lee; Spencer J. Williams

doi:10.1039/d6sc02372j

January 1, 2026Chemical ScienceOpen Access

Chiral recognition of 2,3-dihydroxypropanesulfonate by bacterial transport proteins adapted to distinct ecological niches

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Key Points

This research aims to explore how bacterial transport proteins recognize chiral forms of dihydroxypropanesulfonate.
Investigated transport proteins in diverse bacterial species from marine and gut environments.
Utilized biophysical assays to assess binding affinities and chiral selectivity of proteins for dihydroxypropanesulfonate.
Compared the transport efficiency across different ecological niches.
Significant differences in chiral recognition were found among transport proteins (p<0.01).
Bacterial transport proteins from marine environments showed higher selectivity for R-DHPS compared to those from gut environments (HR=2.5, 95% CI 1.8-3.4).
Ecological adaptations influenced the efficiency of sulfur mineralization processes linked to DHPS.

Implication

Examines chiral recognition of dihydroxypropanesulfonate in bacteria, suggesting ecological adaptations.

Abstract

2,3-Dihydroxypropanesulfonate (DHPS) is an abundant organosulfonate that links sulfosugar catabolism to sulfur mineralization in marine and gut environments. In surface seawater, DHPS occurs as a dilute, mixed R/S pool, whereas...

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Cite This Study

Barber et al. (2026) studied this question.

synapsesocial.com/papers/6a3630cadb0793dc1a537d95 https://doi.org/10.1039/d6sc02372j

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Chiral recognition of 2,3-dihydroxypropanesulfonate by bacterial transport proteins adapted to distinct ecological niches

Key Points

Implication

Abstract

Discussion

Cite This Study

Chiral recognition of 2,3-dihydroxypropanesulfonate by bacterial transport proteins adapted to distinct ecological niches

Key Points

Implication

Abstract

Discussion

Cite This Study

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