Influence of cell penetrating peptides on efficiency of lipid nanoparticles containing chemotherapeutics

Cell-penetrating peptides (CPPs) are a group of short peptides that easily pass through the cell membrane and are able to carry various types of cargoes, such as drugs, nucleic acids, and proteins, into cells. Therefore, CPPs are investigated with the aim of effective drug delivery to treat diseases such as cancer, diabetes and genetic disorders. CPPs have different applications in different fields.CPPs have common functions and some structural features, such as a high content of positively charged amino acids, but their structural differences are in the high variety of elements in them. In this paper, the effect of cell penetrating peptides on the efficiency of lipid nanoparticles containing chemotherapeutics is reviewed. Various drug delivery systems such as liposomes, solid lipid nanoparticles and exosomes were considered. Both in-vitro and in-vivo delivery routes were discussed.