First results of a liver-specific Nope knockout mouse model

S. Zweerink; S. Schulte; E. Könze; B. Jakob; S Schmitt; S E Troeder; B. Zevnik; J.-W. Lackmann; C. Neumann-Haefelin; D. Nierhoff

doi:10.3205/26vzmnrw114

June 18, 2026Open Access

First results of a liver-specific Nope knockout mouse model

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Key Points

This research aims to explore the role of Nope, an oncofetal marker, in liver function.
Developed a liver-specific Nope knockout mouse model to examine its function.
Utilized genetic engineering techniques to create the NopeKO mouse.
Initial findings indicate alterations in liver properties without specific measurements due to limited data.

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Implication

Knockout model investigates liver function of Nope, suggesting insights into epithelial cell dynamics.

Abstract

Background and objective: Neighbor of Punc E11 (Nope) is a known oncofetal marker in the liver. To understand the function of this membrane protein that is preferentially expressed by epithelial cells, we developed a liver-specific Nope knockout (KO) mouse. Method: We generated the NopeKO mouse [for full text, please go to the a.m. URL]

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Cite This Study

Zweerink et al. (2026) studied this question.

synapsesocial.com/papers/6a3630f5db0793dc1a53800f https://doi.org/10.3205/26vzmnrw114

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First results of a liver-specific Nope knockout mouse model

Key Points

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Implication

Abstract

Discussion

Cite This Study

First results of a liver-specific Nope knockout mouse model

Key Points

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Implication

Abstract

Discussion

Cite This Study

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