Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]

Fang Wang; Hai Li; Xiao-Gang Yan; Zhi-Wei Zhou; Zhi-Gang Yi; Zhi-Xu He; Pan S; Yin-Xue Yang; Zuo-Zheng Wang; Xueji Zhang; Tianxing Yang; Jia-Xuan Qiu; Shu-Feng S Zhou

doi:10.2147/dddt.s633636

June 1, 2026Drug Design Development and TherapyOpen Access

Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]

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Key Points

This study aimed to investigate the effects of alisertib on cell cycle arrest and other cellular processes in pancreatic cancer cells.
Analysis of alisertib's role in cell cycle modulation, autophagy induction, and epithelial-to-mesenchymal transition suppression.
Evaluation of the involvement of PI3K/Akt/mTOR and Sirtuin 1 signaling pathways.
Alisertib was reported to induce cell cycle arrest and promote autophagy.
Epithelial-to-mesenchymal transition was suppressed, indicating potential anti-cancer effects.

Implication

Retraction of findings on alisertib's impact on cellular processes in pancreatic cancer cells, suggesting potential limitations.

Abstract

Retraction for the article Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a3631cedb0793dc1a5389c6 https://doi.org/10.2147/dddt.s633636

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Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]

Key Points

Implication

Abstract

Discussion

Cite This Study

Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]

Key Points

Implication

Abstract

Discussion

Cite This Study

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