Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells Retraction

Key Points

• This study aimed to investigate the effects of alisertib on cell cycle arrest and other cellular processes in pancreatic cancer cells.
• Analysis of alisertib's role in cell cycle modulation, autophagy induction, and epithelial-to-mesenchymal transition suppression.
• Evaluation of the involvement of PI3K/Akt/mTOR and Sirtuin 1 signaling pathways.
• Alisertib was reported to induce cell cycle arrest and promote autophagy.
• Epithelial-to-mesenchymal transition was suppressed, indicating potential anti-cancer effects.