Amide α-C-H Oxidative Coupling Reactions Enabled by Base-Promoted Halogen Transfer

Faith E. Kidd; Cristian Vásquez Tapia Vera; Jeffrey S. Bandar

doi:10.1039/d6sc02461k

January 1, 2026Chemical ScienceOpen Access

Amide α-C-H Oxidative Coupling Reactions Enabled by Base-Promoted Halogen Transfer

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Key Points

The study aims to develop a base-promoted method for the oxidative coupling of amide α-C-H bonds with various pronucleophiles.
Developed a protocol using base promotion for halogen transfer.
Investigated the coupling of amide α-C-H bonds with O-, S-, and N-pronucleophiles.
Utilized deprotonation, halogenation, and substitution in the reaction mechanism.
Successfully coupled amide α-C-H bonds with multiple pronucleophiles.
Demonstrated a unique reaction mechanism involving synergistic interactions.
Showed high efficiency and versatility of the protocol in organic synthesis.

Implication

Research demonstrates a novel base-promoted method for oxidative coupling in amides, highlighting its utility in organic synthesis.

Abstract

A base-promoted protocol for the direct oxidative coupling of amide α-C-H bonds with common O-, S-, and N-pronucleophiles is described. This process operates via a synergistic deprotonation, halogenation, and substitution...

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Cite This Study

Kidd et al. (2026) studied this question.

synapsesocial.com/papers/6a3631fbdb0793dc1a538a6d https://doi.org/10.1039/d6sc02461k

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Amide α-C-H Oxidative Coupling Reactions Enabled by Base-Promoted Halogen Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

Amide α-C-H Oxidative Coupling Reactions Enabled by Base-Promoted Halogen Transfer

Key Points

Implication

Abstract

Discussion

Cite This Study

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