Retrospective analysis reveals high prevalence of Alzheimer’s disease and risk factors in transgender adults, suggesting urgent need for tailored interventions.
Purpose: This study determined the prevalence of Alzheimer’s disease and related dementias (ADRD) and associated modifiable risk factors among transgender adults in South Carolina. Methods: This retrospective analysis of all-payer hospital claims data from South Carolina (2000–2022) included adults aged ≥18 years. ADRD and risk factor prevalence were estimated overall and stratified by age group (18–49 and ≥50 years). Transgender adults and ADRD diagnoses were identified using International Classification of Diseases codes. Results were compared to state prevalence rates. Results: Among 1160 transgender adults, ADRD prevalence was 19.4% among those aged ≥50 years and 1.3% among those aged 18–49 years; depression (61.7%), smoking (49.6%), and hypertension (38.2%) were the most common risk factors. Conclusion: Transgender adults in South Carolina experience a substantial burden of ADRD and modifiable risk factors, warranting targeted and culturally competent interventions for this population.
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May et al. (2026) studied this question.
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