ABSTRACT Background Autologous scalp‐derived micrografts (MG) and allogeneic dental pulp stem cell‐derived conditioned medium obtained from stem cells from human exfoliated deciduous teeth (SHED‐CM) have individually shown efficacy in treating male androgenetic alopecia (MAGA). Objectives To evaluate the efficacy and safety of combined MG and SHED‐CM treatment (MGCM) and to identify trichoscopic parameters associated with inter‐individual variability in treatment responses. Methods Fifty‐nine patients with vertex type MAGA received one MG session and four SHED‐CM injections. Global and hair‐whorl images, along with quantitative trichoscopic parameters, were assessed at baseline and 12 months. Overall response was evaluated using a composite Quantitative Trichoscopic Evaluation System (QTES) Score derived from representative trichoscopic parameters. Results MGCM achieved a response rate of 69.5% without serious adverse events. Mild, self‐limited injection‐site pain and petechiae were noted in 33.9% of patients. Responders showed increases in hair diameter and hair number per follicular unit (HN/FU), whereas non‐responders exhibited a decline in HN/FU. HN/FU most clearly discriminated responders from non‐responders, both individually and within the composite QTES Score. Inter‐assessor reliability demonstrated good to excellent agreement. Conclusions MGCM was well‐tolerated and resulted in clinically meaningful improvement in a substantial proportion of patients with MAGA. Changes in HN/FU, integrated within the composite QTES Score, provide a practical and appearance‐relevant marker of treatment response. These findings support the use of integrated quantitative trichoscopic assessment for monitoring and predicting treatment outcomes.
Kamishima et al. (Mon,) studied this question.