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This case highlights the rare occurrence of early-onset low-grade glioma in infants and the implications of molecular profiling for prognosis and treatment.

June 20, 2026Clinical Case ReportsOpen Access

Early‐Onset Medullocervical Low‐Grade Glioma With FGFR1 Mutation and Leptomeningeal Spread in an Infant: A Case Report

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Authors

TTThaer A. Tumar MSMahdi W. Suboh MAMones H. Atatre

Discussion

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Overview

Case report reveals FGFR1-mutated low-grade glioma progression in an infant, suggesting advanced diagnostics improve treatment outcomes.

Key Points

This case highlights the rare occurrence of early-onset low-grade glioma in infants and the implications of molecular profiling for prognosis and treatment.
Case report of a four-month-old female with early-onset medullocervical low-grade glioma and leptomeningeal spread.
Histological and molecular analyses confirmed the FGFR1 mutation and classified the tumor subtype.
Targeted therapy with trametinib was administered following initial surgical interventions.
Initial treatment led to a partial radiologic response, but the tumor progressed with cervical cord extension and leptomeningeal metastases.
Histological examination confirmed a low-grade glioneuronal tumor despite aggressive behavior and low proliferative activity.
The patient remains clinically stable under ongoing targeted therapy and multidisciplinary care.

Cite This Study

Tumar et al. (2026) studied this question.

synapsesocial.com/papers/6a363274db0793dc1a5390bc https://doi.org/10.1002/ccr3.72974

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June 20, 2026Clinical Case ReportsOpen Access

Early‐Onset Medullocervical Low‐Grade Glioma With FGFR1 Mutation and Leptomeningeal Spread in an Infant: A Case Report

View Full Paper

Ask AI

Bookmark

Authors

TTThaer A. Tumar MSMahdi W. Suboh MAMones H. Atatre

Discussion

Member takes

Overview

Case report reveals FGFR1-mutated low-grade glioma progression in an infant, suggesting advanced diagnostics improve treatment outcomes.

Key Points

This case highlights the rare occurrence of early-onset low-grade glioma in infants and the implications of molecular profiling for prognosis and treatment.
Case report of a four-month-old female with early-onset medullocervical low-grade glioma and leptomeningeal spread.
Histological and molecular analyses confirmed the FGFR1 mutation and classified the tumor subtype.
Targeted therapy with trametinib was administered following initial surgical interventions.
Initial treatment led to a partial radiologic response, but the tumor progressed with cervical cord extension and leptomeningeal metastases.
Histological examination confirmed a low-grade glioneuronal tumor despite aggressive behavior and low proliferative activity.
The patient remains clinically stable under ongoing targeted therapy and multidisciplinary care.

Cite This Study

Tumar et al. (2026) studied this question.

synapsesocial.com/papers/6a363274db0793dc1a5390bc https://doi.org/10.1002/ccr3.72974

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