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June 20, 2026Global Implementation Research and ApplicationsOpen Access

Developing Implementation Strategies for Targeted Next-Generation Sequencing for Tuberculosis Diagnosis in Botswana: A Study Protocol

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Authors

SMStephen MolldremKKKeolebogile KereeditseSBSedilame Bagani

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Overview

Study protocol develops implementation strategies for targeted genomic drug resistance testing in Botswana, highlighting key barriers and facilitators.

Key Points

  • This study aims to develop implementation strategies for targeted next-generation sequencing to improve tuberculosis diagnosis and management in Botswana.
  • Identify barriers and facilitators in Botswana's TB care cascade through qualitative methods.
  • Interview TB stakeholders and affected individuals to gather insights on challenges in TB management.
  • Workshop strategies in focus groups to finalize preferred implementation packages.
  • Implementation strategies will be tailored based on findings from stakeholder interviews and qualitative analysis.
  • Sustainable strategies are expected to enhance the effectiveness of targeted sequencing in TB management.
  • Results aim to provide a framework applicable to other low-to-middle-income settings.

Cite This Study

Molldrem et al. (2026) studied this question.

synapsesocial.com/papers/6a363274db0793dc1a539126https://doi.org/10.1007/s43477-026-00240-7
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