Impact of PD-1⁺Tim-3⁺CD8⁺ T cells in pretreatment tumors on chemotherapy responses in esophageal cancer.

June 18, 2026

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Key Points

To investigate the role of PD-1+ Tim-3+ CD8+ T cells in predicting chemotherapy responses in esophageal cancer.
Assessed tumor-infiltrating lymphocytes (TILs) in pretreatment tumors of ESCC patients.
Evaluated the correlation between TILs and neoadjuvant chemotherapy response.
Analyzed tumor microenvironment characteristics.
High levels of PD-1+ Tim-3+ CD8+ T cells were associated with poor chemotherapy response.
Patients with elevated TILs exhibited significantly lower response rates to NAC.
Results suggest TILs can serve as biomarkers for predicting chemotherapy efficacy.

Reveals poor chemotherapy response linked to tumor-infiltrating lymphocytes in esophageal cancer, suggesting a need for targeted therapies.

TILs in the pre-treatment tumor microenvironment as a useful predictor of a poor NAC response in ESCC patients.

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Sumimoto et al. (2026) studied this question.

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