Photoluminescence-Based DNA Biosensing of Tuberculosis Using Defect-Rich Cerium Oxide Nanomaterials

Jeba Grace Tigga; Manoj Patel

doi:10.1021/acsaom.6c00198

June 18, 2026ACS Applied Optical Materials

Photoluminescence-Based DNA Biosensing of Tuberculosis Using Defect-Rich Cerium Oxide Nanomaterials

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Key Points

This research aims to develop defect-engineered cerium oxide nanosheets for ultrasensitive DNA detection.
Developed defect-rich cerium oxide nanosheets for biosensing.
Utilized photoluminescence for detecting DNA through changes in PL intensity.
Tested the biosensor in clinical DNA samples for selectivity and sensitivity.
Achieved a linear detection range of 0.35 to 42 pM and a detection limit of 0.179 pM.
Observed significant PL quenching upon hybridization with target DNA through photoinduced electron transfer.
Demonstrated excellent selectivity for target DNA compared to other samples.

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Implication

Demonstrates sensitive DNA detection in clinical samples using cerium oxide nanosheets, indicating new biosensing potential.

Abstract

Defect-engineered cerium oxide (CeO 2 ) nanosheets were developed as a label-free photoluminescence (PL) platform for ultrasensitive DNA detection. The CeO 2 nanosheets exhibited defect-mediated emission associated with oxygen vacancies. Probe DNA (ssDNA) immobilization enhanced PL intensity due to surface passivation, whereas hybridization with complementary target DNA (tDNA) induced significant PL quenching via guanine-mediated photoinduced electron transfer (PET). The biosensor showed a linear detection range of 0.35 to 42 pM with a low detection limit of 0.179 pM. Excellent selectivity and successful detection in clinical DNA samples demonstrate the potential of CeO 2 nanosheets for sensitive optical DNA biosensing.

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Tigga et al. (2026) studied this question.

synapsesocial.com/papers/6a3632d2db0793dc1a5395b1 https://doi.org/10.1021/acsaom.6c00198

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Photoluminescence-Based DNA Biosensing of Tuberculosis Using Defect-Rich Cerium Oxide Nanomaterials

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Abstract

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Cite This Study

Photoluminescence-Based DNA Biosensing of Tuberculosis Using Defect-Rich Cerium Oxide Nanomaterials

Key Points

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Implication

Abstract

Discussion

Cite This Study

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