Canagliflozin significantly reduced serum creatine kinase-myocardial band, triglycerides, cholesterol, and connective tissue growth factor gene expression in isoprenaline-induced cardiac fibrosis.
Does canagliflozin attenuate cardiac fibrosis and oxidative stress in a mouse model of isoprenaline-induced cardiac injury?
Canagliflozin attenuates isoprenaline-induced cardiac fibrosis and oxidative stress in mice, suggesting potential cardioprotective mechanisms beyond glycemic control.
Abstract Background: Canagliflozin, a sodium–glucose cotransporter 2 (SGLT-2) inhibitor approved for type 2 diabetes, has been reported to confer cardiovascular protection beyond glycemic control. Aim: The present study was designed to investigate the cardioprotective potential of canagliflozin in isoprenaline (ISP)-induced cardiac fibrosis in a mouse model. Materials and Methods: Cardiac fibrosis was induced by the subcutaneous administration of ISP (20 mg/kg body weight) for 14 consecutive days. Canagliflozin (10 mg/kg body weight, intraperitoneally) was coadministered to evaluate its protective effects. Serum biochemical parameters, oxidative stress markers, and cardiac fibrosis-related gene expression were analyzed. Results: Canagliflozin coadministration significantly reduced the serum creatine kinase–myocardial band, triglyceride, and cholesterol levels compared to the ISP-only group. A marked decrease in tissue glucosamine level and lipid peroxidation, along with a significant increase in reduced glutathione, was observed. Catalase and superoxide dismutase levels showed mild improvement. Moreover, connective tissue growth factor gene expression was significantly downregulated in the canagliflozin-treated group. Conclusion: Canagliflozin attenuated the ISP-induced cardiac fibrosis by improving antioxidant status, modulating lipid metabolism, and downregulating profibrotic gene expression, suggesting its potential as a therapeutic agent against cardiac fibrosis.
Garg et al. (Thu,) conducted a other in Isoprenaline-induced cardiac fibrosis. Canagliflozin vs. Isoprenaline-only group was evaluated on Serum biochemical parameters, oxidative stress markers, and cardiac fibrosis-related gene expression. Canagliflozin significantly reduced serum creatine kinase-myocardial band, triglycerides, cholesterol, and connective tissue growth factor gene expression in isoprenaline-induced cardiac fibrosis.
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