Shows how nanoclusters affect protein behavior in biomolecular interactions, suggesting new visualization techniques.
displays a spectrum of phase behaviors: independent phase separation with mucin, partial co-condensation with γ-globulin, and robust heterotypic LLPS with bovine serum albumin (BSA), lysozyme, and β-lactoglobulin. Confocal laser scanning microscopy (CLSM) imaging and FRAP analysis reveal that protein co-condensation can modulate condensate diffusivity, with shared compartments dampening dynamics and distinct ones enhancing them. Our findings highlight atomically precise nanoclusters as a powerful alternative luminescent analogue for dissecting biomolecular LLPS and elucidating nanobio interactions.
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Mukhopadhyay et al. (2026) studied this question.
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