(Ultra-)short-acting insulin analogues for adults with type 1 diabetes mellitus on multiple daily injections: a network meta-analysis

Yang Guo; Yuqian Mei; Brenda Bongaerts; Maria‐Inti Metzendorf; Birgit Fullerton; Andrea Siebenhofer; Klaus Jeitler; Karl Horvath; Thomas Semlitsch; Andrea Berghold; Johannes Plank; Nandi Siegfried; Juan Víctor Ariel Franco

doi:10.1002/14651858.cd012161.pub2

June 19, 2026Cochrane library

(Ultra-)short-acting insulin analogues for adults with type 1 diabetes mellitus on multiple daily injections: a network meta-analysis

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Key Points

To compare the effectiveness of (ultra-)short-acting insulin analogues versus regular human insulin in adults with type 1 diabetes on multiple daily injections.
Network meta-analysis of 15 randomized controlled trials (N=6335)
Interventions lasted from 24 to 52 weeks
Utilized frequentist statistical analyses with regular human insulin as a reference
All five (ultra-)short-acting analogues showed little to no difference in HbA1c compared to regular human insulin.
URLi may reduce severe hypoglycaemia (RR: 0.80, 95% CI 0.36 to 1.77), while FIAsp may increase it (OR: 1.18, 95% CI 0.12 to 11.24).
Lispro and URLi may reduce diabetic ketoacidosis (OR: 0.74, 95% CI 0.10 to 5.39) compared to regular human insulin.

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Implication

Randomized trial compares (ultra-)short-acting insulin analogues on glycaemic control in adults with type 1 diabetes, suggesting some benefits for severe hypoglycaemia and DKA.

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Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c59fc1 https://doi.org/10.1002/14651858.cd012161.pub2

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(Ultra-)short-acting insulin analogues for adults with type 1 diabetes mellitus on multiple daily injections: a network meta-analysis

Key Points

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Implication

Discussion

Cite This Study

(Ultra-)short-acting insulin analogues for adults with type 1 diabetes mellitus on multiple daily injections: a network meta-analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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